Research Analytics & Impact Assessment
Knockdown of a regulatory barcode shifts macrophage polarization destination from M1 to M2 and increases pathogen burden upon S. aureus infection
- Organisation
- Indian Institute of Science Bangalore
- Source
- eLife, published
- On SHODHX
ยท Approved by Sameer Gupta
By Sathyabaarathi Ravichandran, Bharat Bhatt, Awantika Shah et al.. Abstract Macrophages are driven to form distinct functional phenotypes in response to different immunological stimuli, in a process widely referred to as macrophage polarization. Transcriptional regulators that guide macrophage polarization in response to a given trigger remain largely unknown. In this study, we interrogate the programmable landscape in macrophages to find regulatory panels that determine the precise polarizatio...
Original report by eLife, .
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